2007年11月28日星期三
Still Eyeing Google, IBM Refreshes Enterprise Search
2007年11月27日星期二
Sell Technical Service
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An Environmental Contaminant Invades the Womb
By Benjamin Lester
ScienceNOW Daily News
26 November 2007
Arsenic contaminates drinking water the world over, entering from both naturally occurring deposits and industrial activities. To meet World Health Organization (WHO) standards for safety, arsenic must not be present in drinking water at concentrations greater than 10 parts per billion, but in some countries, such as Bangladesh, the levels far exceed that danger point. Scientists have linked low, chronic exposure to a host of illnesses including diabetes and cancer. In addition, recent work suggests that arsenic exposure before birth can raise cancer risks later in life, but the mechanism has remained unclear.
Wondering whether genes might play a role, researchers at the Chulabhorn Research Institute in Bangkok, Thailand, led by environmental toxicologist Panida Navasumrit focused on the country's Ron Pibul district. Tin mining from the 1960s to the 1980s contaminated groundwater there with arsenic at levels up to 50 times the WHO limit. The team took blood and fingernail clippings from newborns and their mothers in the region and sent 21 samples to Leona Samson, a molecular biologist at the Massachusetts Institute of Technology in Cambridge. Samson compared the samples to those from 11 babies in Bangkok whose mothers had not been exposed to arsenic. She found that the expression levels of 11 genes were significantly different in newborns with arsenic-exposed mothers. When Samson used these genes as a guide, she could predict with 83%26#37; accuracy whether the remaining 19 babies had been exposed to the environmental contaminant via their mothers.
The 11 genes play roles in cell growth and death as well as in inflammation, the group reported online 23 November in PLoS Genetics. Although it's not yet known exactly how arsenic causes cancer, Samson notes that chronic inflammation has been linked to stomach cancer. "It therefore seems likely that the arsenic-induced inflammatory response plays at least some role in arsenic-induced cancer," she says.
The paper "opens up potentially very interesting avenues of research" into the fetal effects of environmental contaminants, says Michael Waalkes, a toxicologist at the U.S. National Cancer Institute and the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. Still, he notes that the predictive power of the gene set is low, and "because of the experimental design we can't really say that other exposures might [not] be an issue."
Strerch Cord
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What's Next For TomorrowNow?
2007年11月22日星期四
Stocks Tumble Again
2007年11月10日星期六
1000, 000mt / Used Rail
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Buy Fresh Indian Suran
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Buy Invest Agarwood / Gaharu Plantation
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Buy New Aquaculture Technologies
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Purchase hemp protein
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Aluminium Phosphide
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Sell Trike Chopper
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Sell 650&800cc EPA Utility Buggy
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2007年11月9日星期五
Sell Girl's Set
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Sell padded jacket
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Sell KA Fan Reticulate Protective Casing
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Sell Chinese Red Pepper (Chinese Prickly Ash)
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Technical Analysis: Banks Catch a Bid
2007年11月8日星期四
Facebook's Beacon Casts Light On Future Of Web Ads
Fedora 8 'Werewolf' Shows Its Fangs
Microsoft's 'Centro' Finally Gets a Name
2007年11月2日星期五
PrivacyGroupsSeek'DoNotCall'ListforWebAds
2007年11月1日星期四
Stocks Rocket on Rate Cut
Stocks posted strong gains Wednesday after the Federal Reserve cut interest rates by a quarter point but suggested that it was done cutting rates for now.
The Fed gave the market the rate cut it expected, but in its accompanying policy statement, central bankers said that growth will likely slow because of the housing market crisis, but that "the upside risks to inflation roughly balance the downside risks to growth," a neutral statement that essentially warned traders not to expect any more rate cuts for now.
The move followed a Commerce Department report that said the economy grew at a stronger than expected 3.9% pace in the third quarter.
Stocks traded in volatile fashion after the Fed's action, giving up early gains only to close near the highs of the day.
Google closed above $700 a share for the first time on reports that it plans a wireless venture with Verizon. With a $220.7 billion market cap, Google is now the fifth most highly valued U.S. company, behind AT%26T, Microsoft, GE and Exxon Mobil. In recent days, the stock has passed Citigroup, Bank of America, Procter %26 Gamble and Cisco Systems.
Dell rose 2.7% after filing amended financial statements for four years, effectively ending the company's long accounting nightmare and paving the way to resume share buybacks.
Microsoft gained 3.5% to a fresh multiyear high on bullish comments from Sanford Bernstein, as the stock continued to benefit from last week's better than expected earnings report.
Most big technology names posted gains on the day, but Sun Microsystems and eBay traded lower.
SiRF Technology soared 28% after beating estimates, and MicroStrategy, Answerthink, Pericom Semi and CommVault were other earnings gainers.
First Consulting gained 27% on a takeover offer from Computer Sciences, while Garmin fell 10% on its results and an offer to acquire Tele Atlas N.V.
The Nasdaq surged 43 to a new multiyear high of 2859, the S%26P gained 18 to 1549, and the Dow rose 137 to 13,930. Volume rose to 3.67 billion shares on the NYSE, and 2.57 billion on the Nasdaq. Advancers led by a 24-8 margin on the NYSE, and 20-10 on the Nasdaq. Upside volume was 79% on the NYSE, and 74% on the Nasdaq. New highs-new lows were 248-92 on the NYSE, and 159-139 on the Nasdaq.
Google Gadgets Go Into The Wild
Google's announcement of OpenSocial Wednesday night marks something of a turning point for the technology darling.
As the company struggles to extend its dominance in online search advertising to radio, TV and print, the OpenSocial project creates a set of open application programming interfaces (APIs) that will let developers write widgets to run on a variety of social networks, including its own.
Venture Beat published what it said was a draft of the press release, still officially under embargo, which said, "The proliferation of unique APIs across dozens of social Web sites is forcing developers to choose which ones to write applications for %26#150; and then spend their time writing separately for each."
"OpenSocial gives developers of social applications a single set of APIs to learn for their application to run on any OpenSocial-enabled Web site. By providing these simple, standards-based technologies, OpenSocial will speed innovation and bring more social features to more places across the Web."
A Google spokesman said in an e-mail, "There's a lot of innovation that will be spurred simply by creating a standard way for developers to run social applications in more places. With the input and iteration of the community, we hope OpenSocial will become a standard set of technologies for making the Web social."
OpenSocial's purpose is to test the "social graph" concept that illustrates how individuals are connected to others across Web-based applications and discrete social networks like Orkut or Friendster.
According to Marc Andreessen, who co-founded Netscape and the social networking site Ning, OpenSocial is not a Web services API, but rather a way for external applications to plug into a hosted environment, which he dubbed the container.
The external application can make JavaScript calls to retrieve information from the container or perform functions within the container, such as "give me a list of all of this user's friends" or "inject this event into this user's activity feed." Ning is a member of the OpenSocial consortium.
Andreessen said it took only a few days for Ning to implement OpenSocial, adding that Ning, Orkut, Hi5, LinkedIn, iLike, Flixster, and Slide would also demonstrate working code.
While some see OpenSocial as Google's attempt to combat the growing popularity of Facebook with users and advertisers, Andreessen thinks developers will continue to use both because they'll be able to run multiple front-ends%26#151;for Facebook, OpenSocial and others%26#151;with the same back-end code.
LinkedIn founder Adam Nash wrote on his blog that OpenSocial would make it easy for developers to write business applications that LinkedIn users might like.
As Google developer Brad Fitzpatrick, founder of the early blogging community LiveJournal, explained it on his blog, "People are getting sick of registering and re-declaring their friends on every site," and "developing 'social applications' is too much work."
"Facebook's answer seems to be that the world should just all be Facebook apps," he wrote. "While Facebook is an amazing platform and has some amazing technology, there's a lot of hesitation in the developer/Web 2.0 community about being slaves to Facebook, dependent on their continued goodwill, availability, future owners, not changing the rules, etc."
Fitzpatrick's proposed solution was to make the social graph a community asset that would pool data from the various sites without making any one company its owner. As of August 17, he had prototyped a social graph comprising data from five community sites, including working implementations of the APIs, and had established a Google Group for technical discussions.
King of the open APIs
Google has seen terrific usage of its APIs. Its extraordinarily successful and developer-beloved Maps APIs kicked off a cottage industry of mashups, while the enterprise version provides high functionality for business uses. In July, Google opened its proprietary its geo-spatial mark-up language, KML 2.2, to the Open Geospatial Consortium.
But the search giant's stature has not been as large outside of its core competencies; Orkut, its social networking site, had 24.1 million users worldwide in June, according to comScore, compared with 114.1 million for MySpace. And Google Gadgets, its own form of widgets, isn't among the top 10, according to comScore.
OpenSocial could extend Google's reach into widget advertising. It launched a beta service, Google Gadget Ads, in September. Google Gadget Ads lets advertisers develop widgets that are distributed just like ads across Google's advertising network. A standard widget format would make it easier for Google to distribute them to users within other social networks.
The move also strengthens Google's ties to outside developers. They'll need to go to Google's sandbox to test the APIs and their widgets, um, gadgets.
It's interesting to note the clash between the company's old-school PR tactics and the more open attitudes of Silicon Valley startups.
Google planned a splashy launch event Wednesday night, and, according to the blog TechCrunch, made participants sign non-disclosure agreements, yet leaked the story to the New York Times.
Meanwhile, tech gurus like Andreessen, Fitzpatrick and Nash followed developer norms and spoke openly about the projects, spreading the information all over the Web.